I was born and raised on the rubicon, first roll over was when I was 3 on the 'con so I think I could help you. If you are trailering, and don't have a street legal rig, then I would suggest parking at Loon Lake. there are several good spots, and it is generally very safe. I have left tool bags on my flatbed for a week straight and they were there when I got off the trail, the trail is MUCH more tame than when I was in High school and college.
Places you'll want to stop over at is Spider Lake. Spider is behind the Little Sluice and generally takes 3-4 hours to get to from Loon. You can't drive to spider but it is only 20 yards from the sluice and the best camp spot is on the left just before the sluice. all easily within walking distance.
The next good spot to camp is Buck Island, this should take 2-3 hours if you go by the slabs, but the original trail including Big Sluice and Old Sluice will take 4 hours. I have my preferences on camp spots but anywhere is really good there. there is a bear that roams spider and buck, would be a good idea to move your ice chest away from your tent. Maybe even bring a pistol if that is your thing. (I know I bring my .45, but you can scare him off pretty easy, no need to shoot him)
The next spot to camp would be just past Rubicon Springs at the Dirty Dozen site on the left. Nice little pond back there, it takes 3-4 hours from Buck to get there. Then about 4-5 hours out to the highway.
For a 3 night trip, that would be ideal, just make it a LONG day trip back from the springs to Loon. If you have a street legal rig, I would continue through and get a nice hotel in Tahoe for a night. Then take the next day and go back to get your trailer via the highway.
Most people have mechanical issues on the trail, prepare for that. There is no cell reception except for Walker Hill, which is about 2 hours into the trail from Loon. Even there it is spotty. Any weekend will have a pretty decent amount of rigs up there. Keep an eye out for trail markers, they are little Tires on a yellow sign, usually posted into a tree about 10 feet up. Don't drive past the Fiberglass boundary poles. You'll get cited if caught and harassed if locals find you. You can park at the boundary and hike where ever you want. Not much for firewood, so bring you own or rely on pinecones. There is a bridge and restrooms about 1 hour into the trail from Loon. After that there isn't any provisions until Little Sluice, and it is a 15 year old outhouse that is pretty rough. There might be a outhouse at Buck, can't remember. There are many provisions at Rubicon Springs.
The trail is 21 miles from start to finish going that route. It takes most stock type vehicles 2-3 days to get through. in my Ultra4 car, I did the whole trail in 47 minutes but I also hit a top speed of 72 MPH across the Granite Slabs.
(she's a NON-Jeeper).