What do you do with your truck? DD? Trailer queen? Only vehicle?
It makes a big difference!
Example, have what's left of a '85 4runner, had 22re w56 marlin crawler.
Put in 4.3 700r4. Great torque and love the auto BUT hindsight as it is.... Wish I had kept the 22re w56 combo.
Mpg- dropped, reliability-dropped, adapters are Effin expensive! I have more into the swap without paying for the motor and transmission than if I had rebuilt the 22re.
I have to drive mine to the trail and back, still working on keeping it cooled down enough and well guess I'm a little simple!
Sometime in the future I could totally see trading motor trans back to the 22re/w56 set up! Just have to find a local to trade with and well... Start a new build!!
It can be done super clean but takes a lot of time and $.
Reguardless to what v-6 you choose you need a harness, (likely modified) transfer case adapter, lots of time and $ to make it work. Stock transmission can work if you play nice... Most have difficulty with doin that with the extra torque and HP.
My .02
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